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Ann Intern Med. 2002 Feb 19;136(4):280-7.

The stool antigen test for detection of Helicobacter pylori after eradication therapy.

Author information

  • 1Department of Internal Medicine and Gastroenterology, S. Orsola Hospital, via Massarenti 9, 40138 Bologna, Italy. vairadin@med.unibo.it

Abstract

BACKGROUND:

Current noninvasive tests to confirm the eradication of Helicobacter pylori must be performed 4 weeks or more after eradication therapy is completed.

OBJECTIVE:

To determine whether the stool antigen test, a relatively new noninvasive test for H. pylori, administered at various times after eradication therapy correctly identifies persons with persistent H. pylori infection.

DESIGN:

Prospective blinded study.

SETTING:

Six clinical centers in the United States and Europe.

PATIENTS:

84 H. pylori --infected patients undergoing endoscopy for upper abdominal symptoms.

MEASUREMENTS:

At baseline and on day 35 after the completion of triple eradication therapy, all patients underwent endoscopy with histologic examination, rapid urease test and culture, urea breath test, and a stool antigen test. The stool antigen test was also performed on days 3, 7, 15, 21, 28, and 35 after completion of therapy.

RESULTS:

Compared with the gold-standard endoscopic tests on day 35 after antimicrobial therapy, the urea breath test had a sensitivity of 94% (95% CI, 71% to 100%) and a specificity of 100% (CI, 94% to 100%). The stool antigen test had a sensitivity of 94% (CI, 71% to 100%) and a specificity of 97% (CI, 89% to 100%). On day 7 after treatment, the stool antigen test was predictive of eradication (positive predictive value, 100% [CI, 69% to 100%]; negative predictive value, 91% [CI, 82% to 97%]).

CONCLUSION:

A positive result on the stool antigen test 7 days after completion of therapy identifies patients in whom eradication of H. pylori was unsuccessful.

PMID:
11848725
[PubMed - indexed for MEDLINE]
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