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J Interferon Cytokine Res. 2002 Jan;22(1):73-6.

Control of IRF-3 activation by phosphorylation.

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1
Department of Tumor Cell Biology, The Tokyo Metropolitan Institute of Medical Science, Tokyo 113-8613, Japan.

Abstract

Interferon (IFN) regulatory factor-3 (IRF-3) is a unique member of the IRF family. Its transcriptional activity is regulated solely by posttranslational modifications. We review current knowledge of the mechanism of IRF-3 activation: signalling triggered by infections including viruses and bacteria, phosphorylation of IRF-3 on certain serine residues, homodimer formation, and active holocomplex formation with coactivator CBP/p300.

PMID:
11846977
DOI:
10.1089/107999002753452674
[Indexed for MEDLINE]
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