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Clin Immunol. 2002 Feb;102(2):117-34.

A model B-cell superantigen and the immunobiology of B lymphocytes.

Author information

1
Department of Medicine, University of California San Diego, La Jolla, California 92093-0663, USA.

Abstract

Recent reports have shown that protein A of Staphylococcus aureus (SpA) is a specific toxin for B cells by virtue of specific binding interactions with conserved sites on the V(H) region of the B-cell antigen receptor. The structural basis for these Fab-binding interactions has recently been revealed in crystallographic analyses, which have demonstrated many similarities with the interactions of T-cell superantigens. Investigations of the in vivo response to SpA have illustrated how a B-cell superantigen can be used to provide a window for examining fundamental principles that underlie the immunobiology of B lymphocytes.

PMID:
11846453
DOI:
10.1006/clim.2001.5143
[Indexed for MEDLINE]

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