Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2002 Feb 25;12(4):709-13.

New indene-derivatives with anti-proliferative properties.

Author information

1
Max-Planck-Institut fur Molekulare Physiologie, Dortmund, Germany.

Abstract

Metabolites of the non-steroidal anti-inflammatory drug Sulindac inhibit cell proliferation by affecting several intracellular signaling pathways including the tumorigenic Ras/Raf/MAPK pathway. Here, we report the synthesis of eight new indene derivatives derived from the Sulindac structure, and present data on their anti-proliferative properties and their effects on the p21ras protein.

PMID:
11844707
DOI:
10.1016/s0960-894x(01)00839-3
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center