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Bioorg Med Chem Lett. 2002 Feb 25;12(4):575-9.

2-(anilinomethyl)imidazolines as alpha1A adrenergic receptor agonists: 2'-heteroaryl and 2'-oxime ether series.

Author information

1
Division of Chemistry, GlaxoSmithKline, 5Moore Drive, Research Triangle Park, NC 27709, USA. fn28689@gsk.com

Abstract

A series of 2'-heteroaryl and 2'-oxime anilinomethylimidazolines was prepared and evaluated in in vitro functional assays for cloned human alpha1A, alpha1B, and alpha1D receptor subtypes. Potent and selective alpha1A agonists have been identified in these series.

PMID:
11844675
DOI:
10.1016/s0960-894x(01)00822-8
[Indexed for MEDLINE]

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