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Clin Otolaryngol Allied Sci. 2001 Dec;26(6):491-4.

Matrix metalloproteinases 2 and 9 in otitis media with effusion.

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Department of Otorhinolaryngology and Head and Neck Surgery, Queen's Medical Centre, University Hospital, Nottingham, UK.


A qualitative and quantitative study of the presence of matrix metalloproteinase 2 (MMP 2) and matrix metalloproteinase 9 (MMP 9), in the effusions of otitis media with effusion (OME), was performed. The activity of the above enzymes was compared in thick and thin effusions, and concentrations compared in samples from children with one, two, three and four sets of ventilation tubes. The activity of both MMP 2 and MMP 9 was higher in thick than thin effusions, P = 0.07 and P = 0.04, respectively. The concentrations of MMP 9 did not vary with the number of tube insertions but those of MMP 2 did (ANOVA P < 0.05). MMPs may be involved in tympanic membrane damage and prognosis of OME.

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