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J Cell Biochem Suppl. 2001;Suppl 37:106-9.

Computational method to assign microbial genes to pathways.

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Protein Pathways, 1145 Gayley Ave, Suite 304, Los Angeles, California, USA.


We present techniques that mine fully sequenced microbial genomes for functional relationships between genes. We show that genes related by one of four techniques are more likely to belong to the same cellular pathways. Furthermore, we demonstrate that the pathway of an uncharacterized gene may be inferred from those of its functionally related partners. Therefore, we are now able to assign most of the genes within bacteria to cellular pathways.

[Indexed for MEDLINE]

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