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Oncogene. 2001 Dec 20;20(58):8308-16.

The regulation and function of the Id proteins in lymphocyte development.

Author information

1
Division of Biology, 0366, University of California at San Diego, La Jolla, CA 92093, USA. r3@biomail.ucsd.edu

Abstract

Helix-loop-helix (HLH) proteins are essential factors for lymphocyte development and function. One class of HLH proteins, the E-proteins, regulate many aspects of lymphocyte maturation, survival, proliferation, and differentiation. E-proteins are negatively regulated by another class of HLH proteins known as the Id proteins. The Id proteins function as dominant negative inhibitors of E-proteins by inhibiting their ability to bind DNA. Here we discuss the function and regulation of the Id proteins in lymphocyte development.

PMID:
11840323
DOI:
10.1038/sj.onc.1205091
[Indexed for MEDLINE]
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