Send to

Choose Destination
Oncogene. 2001 Dec 20;20(58):8299-307.

Emc, a negative HLH regulator with multiple functions in Drosophila development.

Author information

Centro de BiologĂ­a Molecular Severo Ochoa, Cantoblanco, 28049 Madrid, Spain.


Expression and functional analyses of Emc have demonstrated that it is a prototype for a protein required for multiple processes in development. Initially characterized as a negative regulator of sensory organ development, it was later found to regulate many other developmental processes and cell proliferation. Its ability to block the function of bHLH proteins by forming heterodimers, which are ineffective in DNA binding, accounts for the role of Emc in preventing the acquisition of several cell fates which are under the control of bHLH proteins. However, while maintaining this repressive molecular mechanism, emc also appears to act as a positive regulator of differentiation.

[Indexed for MEDLINE]
Free full text

Publication types, MeSH terms, Substances

Publication types

MeSH terms


LinkOut - more resources

Full Text Sources

Molecular Biology Databases

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center