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Curr Opin Struct Biol. 2002 Feb;12(1):72-81.

Towards the structure of the mammalian signal recognition particle.

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  • 1Biochemie-Zentrum (BZH), University of Heidelberg, Im Neuenheimer Feld 328, D-69120, Heidelberg, Germany.


The signal recognition particle (SRP) is a ubiquitous ribonucleoprotein particle involved in the co-translational targeting of proteins to membranes. Crystal structures are now available for three protein-RNA subcomplexes from the SRP, which give insights into fundamental aspects of protein-RNA recognition, the assembly of stable ribonucleoprotein particles and the mechanism of action of the SRP.

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