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Curr Biol. 2002 Feb 5;12(3):R105-7.

Checkpoints: how to flag up double-strand breaks.

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1
Genome Damage and Stability Centre, University of Sussex, Brighton BN1 9RR, UK.

Abstract

How checkpoint pathways recognise double-strand breaks has long been a mystery. Recent studies have found that two distinct checkpoint protein complexes associate independently with chromatin at the sites of DNA damage. Why do two distinct mechanisms recognise strand lesions, and what does this tell us about the checkpoint pathways?

PMID:
11839292
DOI:
10.1016/s0960-9822(02)00673-5
[Indexed for MEDLINE]
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