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Can J Surg. 2002 Feb;45(1):25-30.

Surgical treatment of thymoma.

Author information

1
Division of Thoracic Surgery, University of Ottawa, Ont.

Abstract

OBJECTIVE:

To describe experience with the surgical treatment of thymoma.

DESIGN:

A retrospective study.

SETTING:

A teaching hospital at the University of Ottawa.

PATIENTS:

Over 25 years, 42 consecutive patients (22 men, 20 women) who had a thymoma requiring operation.

INTERVENTIONS:

Thymectomy.

OUTCOME MEASURES:

Age, sex, association with myasthenia gravis, presence of a paraneoplastic syndrome, extent of surgical resection, tumour size, histologic features of the tumour, clinical staging of the thymoma and short- and long-term outcome after surgery.

RESULTS:

The mean (and standard deviation) age of the patients was 52.8 (12.5) years. Thirteen patients had myasthenia gravis. With respect to tumour staging, 24 patients had stage I, 7 had stage II and 11 had stage III disease. Three patients were lost to follow-up. Radiotherapy was used as an adjunct to surgical treatment in 83% of patients with stages II and III disease. Fifty-one percent of patients available for follow-up survived 175.1 months, and the cumulative 5- and 10-year overall survival rates were 87.3% and 81.4% respectively. Only 1 patient died of metastatic thymoma. Complete or partial remission of myasthenia gravis was seen in 10 (77%) affected patients. Mixed cellular histologic features and a tumour size of less than 115 cm3 were more commonly seen with stage I disease.

CONCLUSIONS:

Thymomas are characterized by slow growth and prolonged survival even in patients with invasive disease as long as the tumour is resected completely and treatment is accompanied by radiotherapy.

PMID:
11837917
PMCID:
PMC3692700
[Indexed for MEDLINE]
Free PMC Article

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