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Genet Couns. 2001;12(4):309-17.

Children with a 22q11 deletion versus children with a speech-language impairment and learning disability: behavior during primary school age.

Author information

  • 1Center for Human Genetics Leuven, Clinical Genetics Unit, University of Leuven, Belgium. ann.swillen@med.kuleuven.ac.be

Abstract

Children with a 22q11 deletion versus children with a speech-language impairment and learning disability: behavior during primary school age: Common behavioral features described in children with the Velo-Cardio-Facial syndrome (VCFS) (del 22q11) are problems with attention and concentration, extremes in behavior and social problems, especially in relationship with peers. At present, it is unclear whether these behavioral manifestations are directly related to the chromosomal anomaly or related to other manifestations of the syndrome such as developmental delay and speech-language delay. This study describes for the first time the behavior of young primary school aged children with a del22q11 compared to a control group of children matched for age, sex and mental level, with similar developmental problems (speech-language impairment plus learning disability: SLI + LD) but without a del22q11 or any other known genetic condition. Parents and teachers evaluated the children's behavior with standardized questionnaires (CBCL; TRF). Results indicate that most of the behaviors are similar across both groups. The only differences found are in the field of <<withdrawn behavior>> and <<aggressive behavior>>. Children with a del22q11 have a stronger tendency to withdraw from others, whereas children with a SLI+LD seem to be more aggressive.

PMID:
11837599
[PubMed - indexed for MEDLINE]
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