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Bioinformatics. 2002 Jan;18(1):213-4.

Geno3D: automatic comparative molecular modelling of protein.

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Institut de Biologie et Chimie des Protéines, IBCP-CNRS UMR 5086, Pôle Bioinformatique Lyonnais, Bioinformatics and structural NMR, 7, Passage du Vercors, 69 367 Lyon Cedex 07, France.


Geno3D ( is an automatic web server for protein molecular modelling. Starting with a query protein sequence, the server performs the homology modelling in six successive steps: (i) identify homologous proteins with known 3D structures by using PSI-BLAST; (ii) provide the user all potential templates through a very convenient user interface for target selection; (iii) perform the alignment of both query and subject sequences; (iv) extract geometrical restraints (dihedral angles and distances) for corresponding atoms between the query and the template; (v) perform the 3D construction of the protein by using a distance geometry approach and (vi) finally send the results by e-mail to the user.

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