Send to

Choose Destination
Proteins. 2002 Mar 1;46(4):405-15.

Automated assignment of SCOP and CATH protein structure classifications from FSSP scores.

Author information

Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot, Israel.


We present an automated procedure to assign CATH and SCOP classifications to proteins whose FSSP score is available. CATH classification is assigned down to the topology level, and SCOP classification is assigned to the fold level. Because the FSSP database is updated weekly, this method makes it possible to update also CATH and SCOP with the same frequency. Our predictions have a nearly perfect success rate when ambiguous cases are discarded. These ambiguous cases are intrinsic in any protein structure classification that relies on structural information alone. Hence, we introduce the "twilight zone for structure classification." We further suggest that to resolve these ambiguous cases, other criteria of classification, based also on information about sequence and function, must be used.

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center