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Ann Neurol. 2002 Feb;51(2):253-6.

Localization of autosomal recessive early-onset parkinsonism to chromosome 1p36 (PARK7) in an independent dataset.

Author information

1
Department of Clinical Genetics, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands. bonifati@kgen.fgg.eur.nl

Abstract

Two new loci, PARK6 and PARK7, for autosomal recessive early-onset parkinsonism have recently been identified on chromosome 1p, in single large pedigrees. Among 4 autosomal recessive early-onset families analyzed here, 2 supported linkage to PARK7, 1 with conclusive evidence. These data confirm localization of autosomal recessive early-onset parkinsonism to PARK7, suggesting it to be a frequent locus. Assignment of families to either PARK6 or PARK7 might be difficult because of the proximity of the two loci on chromosome 1p.

PMID:
11835383
DOI:
10.1002/ana.10106
[Indexed for MEDLINE]

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