Send to

Choose Destination
Arterioscler Thromb Vasc Biol. 2002 Feb 1;22(2):329-34.

Platelet shape changes and adhesion under high shear flow.

Author information

Department of Pediatrics, Nara Medical University, Kashihara, Nara, Japan.


Recent studies have revealed that the platelet adhesive process under flow is tightly regulated by multiple ligand-receptor interactions. However, platelet morphological changes during this process, particularly its physiological relevance, remain unknown under blood flow conditions. Using epifluorescence and scanning electron microscopy, we evaluated the real-time changes in platelet morphology during a platelet adhesive process on a von Willebrand factor-coated surface under physiological high shear flow in a perfusion chamber. Here, we show that dynamic platelet shape changes occurring during distinct phases of the adhesive process are precisely regulated by "inside-out" and "outside-in" integrin signals and are also a key regulatory element in successful platelet thrombogenesis opposing rapid blood flow in vivo.

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center