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Neurosci Lett. 2002 Feb 22;319(3):133-6.

Association of attention deficit hyperactivity disorder-related psychopathology and personality traits with the serotonin transporter promoter region polymorphism.

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  • 1Institute for Forensic Psychiatry, University of the Saarland, Kirrberger Strasse, 66421 Homburg/Saar, Germany.


The role of the genetic polymorphism within the promoter region of the serotonin transporter (5-HTT) gene is under discussion as a modulator for personality traits and a risk factor for several mental disorders including attention deficit hyperactivity disorder (ADHD). Here we report a significant association of this polymorphism with scores on the Wender Utah Rating Scale, which was used for the assessment of a history of ADHD-associated symptoms, indicating a higher frequency of the long variant allele in individuals with high scores. We found no association between the 5-HTT polymorphism and personality traits according to the Eysenck Impulsivity Questionnaire and the Freiburg Personality Inventory, respectively, except a significant association with social orientation. Thus, our study supports the recently reported finding of an association of the 5-HTT polymorphism with ADHD. However, since a dimensional assessment of ADHD-related symptomatology was used in our study instead of a diagnostic approach, we are now on the way in performing further studies regarding diagnostic discrimination and comorbidity.

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