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Ann Thorac Surg. 2002 Jan;73(1):153-5.

Evaluating routine diuretics after coronary surgery: a prospective randomized controlled trial.

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1
Department of Cardiothoracic Surgery, Northern General Hospital, Sheffield, United Kingdom.

Abstract

BACKGROUND:

Routine diuretic administration after cardiopulmonary bypass is common despite the lack of evidence for its benefit. We performed a prospective study to evaluate if diuretics assist in weight loss or alter clinical outcome.

METHODS:

Seventy-nine patients undergoing primary elective coronary bypass surgery were randomized to either diuretic (fusemide and amiloride) or placebo (lactose) postoperatively until preoperative weight was achieved or for 5 days in total. Proportions were compared with chi2 or Fisher's exact test.

RESULTS:

Forty patients were randomized to diuretics and 39 to placebo. By day 5, 97% of patients (37 of 38) still in the diuretic arm, and 74% of patients (29 of 39) in the placebo arm, achieved preoperative weight (p = 0.02). There were no differences in clinical outcomes.

CONCLUSIONS:

Routine diuretics promote an earlier diuresis but no clinical benefits are apparent in low risk patients with normal renal function. Clinicians should reconsider routine diuretic prescription in this setting.

PMID:
11834004
[Indexed for MEDLINE]
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