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World J Gastroenterol. 2002 Feb;8(1):79-81.

Anti-hepatoma activity of resveratrol in vitro.

Author information

1
Department of Hepatobiliary Surgery, First Hospital of Xi'an Jiaotong University Xi'an 710061, Shaanxi Province, China. szhjie@21cn.com

Abstract

AIM:

To study the anti-tumor effect of resveratrol alone and the synergistic effects of resveratrol with 5-FU on the growth of H22 cells line in vitro.

METHODS:

The number of cells was measured by MTT method the morphological changes of H22 cells were investigated under microscopy and electron microscopy examination.

RESULTS:

Resveratrol inhibited the growth of hepatoma cells line H22 in a dose- and time-dependent manner, IC50 of the resveratrol on H22 cells was 6.57mg x L(-1),The synergistic anti-tumor effects of resveratrol with 5-FU increased to a greater extent than for H22 cells treated with 5-FU alone (70.2% vs 28.4%) P<0.05 .Under microscope and electron microscope, characteristics of apoptosis such as typical apoptotic bodies were commonly found in tumor cells in the drug-treated groups.

CONCLUSION:

Resveratrol can suppresses the growth of H22 cells in vitro,its anti-tumor activity may occur through the induction of apoptosis.

PMID:
11833076
PMCID:
PMC4656631
DOI:
10.3748/wjg.v8.i1.79
[Indexed for MEDLINE]
Free PMC Article

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