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J Postgrad Med. 2001 Jul-Sep;47(3):171-6.

Oral cancer among patients under the age of 35 years.

Author information

1
Department of Surgical Oncology, Epidemiology and Clinical studies, Community Oncology and Radiation Oncology, Regional Cancer Centre, Medical College, Thiruvananthapuram - 695 011, India. emathewiype@yahoo.com

Abstract

BACKGROUND:

Cancer of the oral cavity is one of the commonest cancers among males.

AIMS:

To assess the aetiological factors, patient characteristics, treatment and the outcome in young patients with oral cancer.

SETTINGS AND DESIGN:

A retrospective descriptive study of patients under the age of 35 years with cancer of the oral cavity treated between 1982-1996, with the last follow-up till 2001, using the tumour registry data of Regional Cancer Centre (RCC), Trivandrum, Kerala, India.

SUBJECT AND METHOD:

The detailed clinical, treatment and follow-up data were obtained from the computerised records of RCC and recorded on a preset proforma. This was analysed with emphasis on age, sex, risk factors, site, histology, clinical extent and treatment methods and survival in the study group.

STATISTICAL ANALYSIS:

The survival analysis was carried by Kaplan-Meier method and the difference in survival was analysed using log-rank test.

RESULTS:

Out of 264 patients analysed, tongue was the commonest site identified in 136 (52%) patients followed by buccal mucosa in 69 (26%) patients. A male female ratio of 2.3:1 was observed with a significantly higher male preponderance in buccal mucosa (4.3:1). Prior exposure to tobacco or alcohol was noted in 59.4% patients, with more habitu├ęs in buccal mucosa cancer. Histological confirmation was present only in 83.7% patients and among them most were squamous cell carcinoma (85.9%). Radiotherapy, surgery or combined modalities of treatment were employed for majority of patients. The 5-year survival was 57.3%. T stage of the tumour was found to be significant in predicting disease free survival (P=0.03).

CONCLUSIONS:

The importance of early detection for clinical down staging is stressed. There is a need to investigate the aetiology of intra oral cancers in younger patients since a significant proportion (almost 40%) of these patients do not have associated risk factors for cancer.

PMID:
11832617
[Indexed for MEDLINE]
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