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Dev Cell. 2002 Feb;2(2):130-1.

A new clue at the nuclear pore: RanBP2 is an E3 enzyme for SUMO1.

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Laboratory of Gene Regulation and Development, NICHD/NIH, Building 18, Room 106, Bethesda, MD 20892, USA.


A recent paper in Cell shows that the large nucleoporin RanBP2 can act as an E3 enzyme for the ubiquitin-like protein SUMO1. These intriguing results raise important questions about the mechanism of SUMO1 conjugation, the relationship of SUMO1 to nuclear transport, and the regulation of RanBP2 in the pore.

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