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Springer Semin Immunopathol. 2001 Dec;23(4):405-19.

Naive and memory B cells in T-cell-dependent and T-independent responses.

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Division of Hematology, Geneva University Hospital, 1211 Geneva 14, Switzerland.


This review focuses on the properties and roles of distinct subsets among the primary and the memory B lymphocytes regarding their contribution to helper-T-cell-dependent and -independent antibody responses. The naive/memory B cell functions are explained in the context of current concepts on the basic mechanisms of humoral immunity. Differences between murine and human B cells are also discussed.

[Indexed for MEDLINE]

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