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J Clin Pathol. 2002 Jan;55(1):4-13.

Cryoglobulins.

Author information

1
Dipartimento di Medicina Interna, Università di Pisa, Pisa 56126, Italy. c.ferri@int.med.unipi.it

Abstract

Serum cryoglobulins are found in a wide spectrum of disorders but are often transient and without clinical implications. Monoclonal cryoglobulins are usually associated with haematological disorders, whereas mixed cryoglobulins are found in many infectious and systemic disorders. So called essential mixed cryoglobulinaemia shows a striking association with hepatitis C virus (HCV) infection (> 90%). It is a systemic vasculitis (leucocytoclastic vasculitis) with cutaneous and multiple visceral organ involvement. Chronic HCV infection can lead to a constellation of autoimmune and neoplastic disorders. In this review, the aetiology, diagnosis, disease heterogeneity, and treatment of cryoglobulinaemia are discussed.

PMID:
11825916
PMCID:
PMC1769573
DOI:
10.1136/jcp.55.1.4
[Indexed for MEDLINE]
Free PMC Article

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