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Science. 2002 Feb 1;295(5556):813-8.

Signal transduction and the control of gene expression.

Author information

1
Laboratory of Molecular Vertebrate Embryology, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

Abstract

More than 2000 transcription factors are encoded in the human genome. Such proteins have often been classified according to common structural elements. But because transcription factors evolved in the service of biologic function, we propose an alternative grouping of eukaryotic transcription factors on the basis of characteristics that describe their roles within cellular regulatory circuits.

PMID:
11823631
DOI:
10.1126/science.1066355
[Indexed for MEDLINE]

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