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EMBO J. 2002 Feb 1;21(3):195-201.

The connection between transcription and genomic instability.

Author information

1
Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Sevilla 41012, Spain. aguilo@us.es

Abstract

Transcription is a central aspect of DNA metabolism that takes place on the same substrate as replication, repair and recombination. Not surprisingly, therefore, there is a physical and functional connection between these processes. In recent years, transcription has proven to be a relevant player in the maintenance of genome integrity and in the induction of genetic instability and diversity. The aim of this review is to provide an integrative view on how transcription can control different aspects of genomic integrity, by exploring different mechanisms that might be responsible for transcription-associated mutation (TAM) and transcription-associated recombination (TAR).

PMID:
11823412
PMCID:
PMC125829
DOI:
10.1093/emboj/21.3.195
[Indexed for MEDLINE]
Free PMC Article

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