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News Physiol Sci. 2002 Feb;17:1-5.

pH Homeostasis of cellular organelles.

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1
Department of Physiology, University of Geneva, 1211 Geneva 4, Switzerland.

Abstract

An optimal pH is maintained in each secretory and endocytic organelle by the balance between active H(+) pumping and passive H(+) efflux. The progressive acidification of secretory organelles does not reflect an increased proton pumping activity but rather the decreased conduction of a "proton leak" pathway resembling the recently cloned voltage-gated proton channels.

PMID:
11821527
[Indexed for MEDLINE]
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