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Fertil Steril. 2002 Feb;77(2):309-12.

PROGINS receptor gene polymorphism is associated with endometriosis.

Author information

1
Department of Obstetrics and Gynecology, Division of Gynecological Endocrinology and Reproductive Medicine, University of Vienna, Waeringer Guertel 18-20, A-1090 Vienna, Austria.

Abstract

OBJECTIVE:

To investigate the association between the 306-base pair insertion polymorphism in intron G of the progesterone receptor (PROGINS) and endometriosis.

DESIGN:

Case-control study.

SETTING:

Tertiary care center.

PATIENT(S):

Ninety-five white women with surgically diagnosed and histologically confirmed endometriosis and 107 white women without endometriosis (controls).

INTERVENTION(S):

Determination of PROGINS was performed by polymerase chain reaction and gel electrophoresis. MAIN OUTCOIME MEASURE(S): Frequency and distribution of the PROGINS allele.

RESULT(S):

Frequencies of the mutant allele T2 was 0.17 among women with endometriosis and 0.08 among controls (odds ratio, 2.41 [CI, 1.31-4.53]). Homozygosity for allele T2 was present in 3.2% of women with endometriosis and 0.9% of controls.

CONCLUSION(S):

PROGINS appears to be associated with endometriosis in white persons.

PMID:
11821088
[Indexed for MEDLINE]
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