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Fertil Steril. 2002 Feb;77(2):270-3.

Efficacy and safety of recombinant human follicle-stimulating hormone in men with isolated hypogonadotropic hypogonadism.

Author information

1
Centre for Neuro-endocrinology, Royal Free Hospital, London, United Kingdom.

Abstract

OBJECTIVE:

To assess the efficacy and safety of recombinant human follicle-stimulating hormone (rhFSH; follitropin alpha) in increasing sperm concentration in 26 men with severe isolated hypogonadotropic hypogonadism (IHH).

DESIGN:

Clinical and endocrine studies using an open design.

SETTING:

Six university clinical sites in three European countries.

PATIENT(S):

Azoospermatic patients aged 16 to 48 years with IHH.

INTERVENTION(S):

Patients received hCG for up to 6 months before 18 months of treatment with rhFSH. Sperm count, motility, and morphology were assessed every 3 months.

MAIN OUTCOME MEASURE(S):

Achievement of a sperm concentration of 1.5 x 10(6)/mL.

RESULT(S):

Spermatogenesis was achieved in 15 of 19 patients who could be evaluated, 12 achieving a sperm concentration of > or =1.5 x 10(6)/mL.

CONCLUSION(S):

With hCG, rhFSH is effective in initiating spermatogenesis in patients with IHH, and is well tolerated.

PMID:
11821082
[Indexed for MEDLINE]

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