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FEBS Lett. 2002 Jan 30;511(1-3):102-6.

Conversion of L-tryptophan to serotonin and melatonin in human melanoma cells.

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1
Department of Pathology, University of Tennessee Health Science Center, Memphis, TN 38163, USA. aslominski@utmem.edu

Abstract

We showed in human melanoma cells tryptophan hydroxylase (TPH) and hydroxyindole methyltransferase genes expression with the sequential enzymatic activities of TPH, serotonin (Ser) N-acetyltransferase and hydroxyindole methyltransferase. The presence of the products Ser, 5OH-tryptophan, N-acetylserotonin, melatonin (Mel), 5-methoxytryptamine and 5-methoxytryptophol was documented by liquid chromatography-mass spectrometry. Thus, human melanoma cells can synthesize and metabolize Ser and Mel.

PMID:
11821057
[Indexed for MEDLINE]
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