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Acta Haematol. 2002;107(1):29-34.

Apoptosis-regulating proteins and prognosis in diffuse large B cell non-Hodgkin's lymphomas.

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1
Hematology Hemotherapy Center, State University of Campinas, Cidade Universitária Zeferino Vaz s/n, Campinas-SP, Brazil.

Abstract

We evaluated the expression of apoptosis-regulating proteins (p53, Bcl-2, Bax, Bak and Mcl-1) in paraffin-embedded tissues of 33 patients with diffuse large B cell non-Hodgkin's lymphoma, and assessed the relationship of these proteins to clinical outcome and response to chemotherapy. Our results showed that p53 expression was an independent immunohistochemical parameter related to a poor prognosis in these lymphomas. Bcl-2, Bax, Bak and Mcl-1 proteins, though highly expressed in almost all cases were not associated with prognosis or response to treatment.

PMID:
11818669
DOI:
10.1159/000046626
[Indexed for MEDLINE]

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