Antisense transcripts in the human genome

Trends Genet. 2002 Feb;18(2):63-5. doi: 10.1016/s0168-9525(02)02598-2.

Abstract

By a systematic search of vertebrate mRNA sequences, we have identified a surprisingly large number of human antisense transcripts. These data suggest that regulation of gene expression by antisense and double-stranded RNAs could be a common phenomenon in mammalian cells.

MeSH terms

  • Algorithms
  • Animals
  • Chromosome Mapping
  • DNA Repair
  • DNA, Antisense
  • Databases, Nucleic Acid
  • Gene Expression Regulation
  • Genome, Human*
  • Humans
  • Mammals / genetics
  • Proteins / genetics
  • Proteins / metabolism
  • RNA, Messenger / genetics

Substances

  • DNA, Antisense
  • Proteins
  • RNA, Messenger