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Curr Biol. 2002 Jan 22;12(2):R50-2.

RNA processing: splicing and the cytoplasmic localisation of mRNA.

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Wellcome/CRC Institute, Department of Genetics, University of Cambridge, Tennis Court Road, CB2 1QR, Cambridge, UK.


An unexpected link has been discovered between pre-mRNA splicing in the nucleus and mRNA localisation in the cytoplasm. The new findings suggest that recruitment of the Mago Nashi and Y14 proteins upon splicing of oskar mRNA is an essential step in the localisation of the RNA to the posterior pole of the Drosophila oocyte.

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