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J Mol Neurosci. 2001 Oct;17(2):233-57.

Genetically engineered models relevant to neurodegenerative disorders: their value for understanding disease mechanisms and designing/testing experimental therapeutics.

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1
Department of Pathology The Johns Hopkins University School of Medicine, Baltimore, MD 21205-2196, USA.

Abstract

Significant progress in the identification of disease-specific genes for a variety of neurodegenerative diseases have provided opportunities to understand molecular mechanisms and to test experimental therapeutic for these disorders. Recent works on clarifying the selective vulnerability of neurons and pathogenic mechanisms using genetically engineered mouse models of familial forms of Alzheimer's disease and motor neuron disease will be reviewed.

PMID:
11816796
DOI:
10.1385/JMN:17:2:233
[Indexed for MEDLINE]
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