Format

Send to

Choose Destination
See comment in PubMed Commons below
Acta Haematol. 2001;106(4):148-56.

The role of vascular endothelial growth factor in angiogenesis.

Author information

1
Department of Molecular Oncology, Genentech, Inc, South San Francisco, Calif 94080, USA. nf@gene.com

Abstract

Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen and an angiogenic inducer as well as a mediator of vascular permeability. The biological effects of VEGF are mediated by two tyrosine kinase receptors, Flt-1 (VEGFr-1) and KDR (VEGFR-2). VEGF is essential for developmental angiogenesis and is also required for female reproductive functions and endochondral bone formation. Substantial evidence also implicates VEGF in tumors and intraocular neovascular syndromes. Currently, several clinical trials are ongoing to test the hypothesis that inhibition of VEGF activity may be beneficial for these conditions.

PMID:
11815711
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center