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Bioorg Med Chem Lett. 2002 Feb 11;12(3):471-5.

alpha(1)-Adrenoceptor agonists: the identification of novel alpha(1A )subtype selective 2'-heteroaryl-2-(phenoxymethyl)imidazolines.

Author information

1
GlaxoSmithKline Research and Development, 5 Moore Drive, Research Triangle Park, NC 27709, USA.mjb45288@glaxowellcome.com

Abstract

Novel 2'-heteroaryl-2-(phenoxymethyl)imidazolines have been identified as potent agonists of the cloned human alpha(1)-adrenoceptors in vitro. The nature of the 2'-heteroaryl group can have significant effects on the potency, efficacy, and subtype selectivity in this series. alpha(1A) Subtype selective agonists have been identified.

PMID:
11814822
DOI:
10.1016/s0960-894x(01)00764-8
[Indexed for MEDLINE]

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