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Bioorg Med Chem Lett. 2002 Feb 11;12(3):423-5.

4-Anilino-3-cyanobenzo[g]quinolines as kinase inhibitors.

Author information

1
Chemical Sciences, Wyeth-Ayerst Research, Pearl River, NY 10965, USA. zhangn@war.wyeth.com

Abstract

A series of 4-anilino-3-cyanobenzo[g]quinolines was prepared as potent kinase inhibitors. Compared with their bicyclic 4-anilino-3-cyanoquinoline analogues, the tricyclic 4-anilino-3-cyanobenzo[g]quinolines are less active against EGF-R kinase, equally active against MAPK kinase (MEK), and more active against Src kinase. For Src kinase inhibition, the best activity is obtained when both the 7- and 8-positions are substituted with alkoxy groups. Several of these kinase inhibitors show potent growth inhibitory activity in tumor cells.

PMID:
11814812
DOI:
10.1016/s0960-894x(01)00776-4
[Indexed for MEDLINE]

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