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Bioorg Med Chem Lett. 2002 Feb 11;12(3):307-10.

Studies toward the discovery of the next generation of antidepressants. Part 2: incorporating a 5-HT(1A) antagonist component into a class of serotonin reuptake inhibitors.

Mewshaw RE1, Meagher KL, Zhou P, Zhou D, Shi X, Scerni R, Smith D, Schechter LE, Andree TH.

Author information

1
Global Chemical Sciences and Neuroscience Departments, Wyeth-Ayerst Research Laboratories, PO Box 42528, Philadelphia, PA 19101-2528, USA. mewshar@war.wyeth.com

Abstract

The design and synthesis of a novel series of indole derivatives (9) having dual 5-HT transporter reuptake and 5-HT(1A) antagonist activity are described.

PMID:
11814784
DOI:
10.1016/s0960-894x(01)00746-6
[Indexed for MEDLINE]

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