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Bioorg Med Chem Lett. 2002 Feb 11;12(3):295-8.

A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain.

Author information

1
PET Facility, Department of Radiology, University of Pittsburgh, PA 15213, USA. mathisca@msx.upmc.edu

Abstract

The synthesis of a new lipophilic thioflavin-T analogue (2-[4' -(methylamino)phenyl]benzothiazole, 6) with high affinity for amyloid is reported. Intravenous injection of [(11)C]-labeled 6 in control mice resulted in high brain uptake. Amyloid deposits were imaged with multiphoton microscopy in the brains of living transgenic mice following the systemic injection of unlabeled 6. [(11)C]6 is a promising amyloid imaging agent for Alzheimer's disease.

PMID:
11814781
[Indexed for MEDLINE]

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