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FEMS Microbiol Lett. 2002 Jan 10;206(2):143-9.

Role of membranes in the activities of antimicrobial cationic peptides.

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Department of Microbiology and Immunology, University of British Columbia, 300-6174 University Blvd, Vancouver, BC, Canada V6T 1Z3.


Cationic amphiphilic peptides that are found throughout nature have very broad-spectrum activities against microbes. The initial sites of interaction are with microbial membranes. Although dogma suggests that their lethal action involves disruption of the cytoplasmic membranes, a number of cationic peptides can traverse intact membranes to interact with internal targets.

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