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Nat Immunol. 2002 Feb;3(2):127-34. Epub 2002 Jan 7.

Dual receptor T cells extend the immune repertoire for foreign antigens.

Author information

1
Section of Immunobiology, Yale University School of Medicine, 310 Cedar St., New Haven, CT 06520-8011, USA. xin.he@yale.edu

Abstract

Since the discovery of T cells that express two T cell receptors (TCRs), termed dual TCR cells, most studies have focused on their autoimmune potential, while their beneficial roles remained elusive. We identified, in normal mice, dual TCR cells that participated in the immune response to a foreign antigen. Unlike single TCR cells, dual TCR cells used the nonselected TCR to respond in the periphery, but relied on coexpression of a second TCR for intrathymic selection. We found that they were selected at low frequency in the naïve repertoire, but dominated the response to antigen through clonal expansion. Thus, dual TCR cells can extend the TCR repertoire for foreign antigens by rescuing functional TCRs that cannot be selected on single TCR cells; they can, therefore, benefit the immune system.

PMID:
11812989
DOI:
10.1038/ni751
[Indexed for MEDLINE]

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