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J Infect Dis. 2002 Feb 1;185(3):375-9. Epub 2002 Jan 9.

Recurrent urinary tract infections in infancy: relapses or reinfections?

Author information

1
Hospital for Children and Adolescents, University of Helsinki, Finland. maria.jantunen@ktl.fi

Abstract

Seventeen infants with an index episode of pyelonephritis caused by Escherichia coli were monitored for 18 months for recurrent urinary tract infections (UTIs). All the infants had at least 1 recurrent UTI caused by the same pathogen. Twenty-six recurrent UTI episodes were recorded. The 40 E. coli strains available were analyzed by multiplex polymerase chain reaction for 3 alleles (classes I-III) of the papG gene and by pulsed-field gel electrophoresis (PFGE) after genomial digestion by XbaI. Of the 17 index strains, 12 (71%) carried the papG gene; 67% of these strains had class II alleles. In recurrent UTI isolates, the papG-positive E. coli appeared in 16 (70%) of 23 isolates. The proportion of all recurrent isolates available that represented a strain previously encountered (indistinguishable or highly similar in PFGE) in the same infant was 65%. Our results suggest that most recurrent UTIs in infants are endogenous relapses rather than reinfections caused by new organisms.

PMID:
11807720
DOI:
10.1086/338771
[Indexed for MEDLINE]

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