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Mol Cell. 2002 Jan;9(1):8-9.

The spliceosome: no assembly required?

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Center for RNA Molecular Biology, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, 44106, Cleveland, OH, USA


In this issue of Molecular Cell, Stevens et al. purify a large particle from yeast extracts that contains all five of the U snRNPs required for pre-mRNA splicing. The existence of this "penta-snRNP" suggests the provocative possibility that spliceosome assembly does not depend upon a pre-mRNA substrate.

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