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Mol Cell. 2002 Jan;9(1):1-3.

Remodeling for demolition: changes in mitochondrial ultrastructure during apoptosis.

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The Burnham Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037, USA.


The release of Cytochrome c from mitochondria is a pivotal event in the apoptotic process, but the precise mechanisms remain controversial. A recent paper proposes that this involves two steps, one involving permeabilization of the mitochondrial outer membrane and a second in which the structural organization of the cristae changes to make Cytochrome c accessible for release. Both events are induced by proapoptotic members of the Bcl-2 family and appear to be separable.

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