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Mol Psychiatry. 2002;7(1):21-6.

Cocaine, reward, movement and monoamine transporters.

Author information

1
Molecular Neurobiology Branch, NIDA-IRP, NIH, Baltimore, MD 21224, USA. guhl@intra.nida.nih.gov

Abstract

Recent evidence enriches our understanding of the molecular sites of action of cocaine reward and locomotor stimulation. Dopamine transporter blockade by cocaine appears a sufficient explanation for cocaine-induced locomotion. Variation in DAT appears to cause differences in locomotion without drug stimulation. However, previously-held views that DAT blockade was the sole site for cocaine reward have been replaced by a richer picture of multitransporter involvement with the rewarding and aversive actions of cocaine. These new insights, derived from studies of knockout mice with simultaneous deletions and/or blockade of multiple transporters, provide a novel model for the rewarding action of this heavily-abused substance and implicate multiple monoamine systems in cocaine's hedonic activities.

PMID:
11803442
DOI:
10.1038/sj/mp/4000964
[Indexed for MEDLINE]
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