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Crit Care Med. 2001 Dec;29(12):2383-5.

Successful treatment of vancomycin-resistant enterococcus meningitis with linezolid: case report and review of the literature.

Author information

1
Department of Neurosurgery, Cleveland Clinic Foundation, Cleveland, OH, USA.

Abstract

OBJECTIVE:

To describe the successful treatment of a case of vancomycin-resistant enterococcus meningitis with linezolid.

DESIGN:

Case report and review of the literature.

PATIENTS:

The patient is a 35-yr-old man who suffered a cerebellar hemorrhage after embolization of a cerebellar arteriovenous malformation. The patient underwent ventriculostomy drainage and craniectomy. The patient was on broad-spectrum antibiotics for pneumonia including vancomycin. The patient remained febrile and grew vancomycin-resistant Enterococcus faecium from the cerebrospinal fluid.

INTERVENTIONS:

The patient was treated with intravenous chloramphenicol without success. On postoperative day 16, the patient was begun on intravenous linezolid.

MAIN RESULTS:

The patient received 4 wks of intravenous linezolid with complete eradication of the meningitis.

CONCLUSIONS:

Intravenous linezolid appears to be a safe and effective therapy for vancomycin-resistant enterococcus meningitis.

[Indexed for MEDLINE]

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