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J Ethnopharmacol. 2002 Feb;79(2):221-7.

Inhibition of human leukocyte function, alanyl aminopeptidase (APN, CD13) and dipeptidylpeptidase IV (DP IV, CD26) enzymatic activities by aqueous extracts of Cistus incanus L. ssp. incanus.

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Institute of Experimental Internal Medicine, Center of Internal Medicine, Otto-von-Guericke University Magdeburg, Leipziger Str. 44, D-39120 Magdeburg, Germany.


Short-boiled aqueous extract from leaves of Cistus incanus L. ssp. incanus (CIT) dose-dependently inhibit the enzymatic activities of both alanyl aminopeptidase (APN, CD13, EC and dipeptidylpeptidase IV (DP IV, CD26, EC This inhibition is not reversible and very likely results from a covalent binding of reactive compounds to the enzymes. Furthermore, we show that aqueous CIT extracts decrease the DNA-synthesis of human T cells and mononuclear cells and inhibit the proliferation rate of the human T cell line KARPAS-299 in a dose-dependent manner. Data are presented suggesting that the antiproliferative effects of CIT extracts are due to their strong cytotoxic activity.

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