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Nutr Cancer. 2001;40(1):12-7.

Se-methylselenocysteine: a new compound for chemoprevention of breast cancer.

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1
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA. dmedina@bcm.tmc.edu

Abstract

Selenium compounds have attracted renewed interest as chemopreventive agents for human cancer on the basis of the pioneering intervention study by Clark and co-workers. The rodent mammary gland has been used extensively as a model for examining the chemopreventive activities of inorganic and organic selenium compounds. This review summarizes the rationale and results for use of a new organic selenium compound, Se-methylselenocysteine, which exhibits greater efficacy as a chemopreventive agent than several previously used selenium compounds in experimental models of breast cancer and has potential for use in human populations.

PMID:
11799917
DOI:
10.1207/S15327914NC401_5
[Indexed for MEDLINE]
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