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Science. 2002 Jan 18;295(5554):502-5.

Regulation of life-span by germ-line stem cells in Caenorhabditis elegans.

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  • 1Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94143-0448, USA.

Abstract

The germ line of the nematode Caenorhabditis elegans influences life-span; when the germ-line precursor cells are removed, life-span is increased dramatically. We find that neither sperm, nor oocytes, nor meiotic precursor cells are responsible for this effect. Rather life-span is influenced by the proliferating germ-line stem cells. These cells, as well as a downstream transcriptional regulator, act in the adult to influence aging, indicating that the aging process remains plastic during adulthood. We propose that the germ-line stem cells affect life-span by influencing the production of, or the response to, a steroid hormone that promotes longevity.

PMID:
11799246
DOI:
10.1126/science.1065768
[PubMed - indexed for MEDLINE]
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