Format

Send to

Choose Destination
See comment in PubMed Commons below
Genes Dev. 2002 Jan 15;16(2):165-70.

Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10.

Author information

1
Institut für Biochemie, Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.

Abstract

Sox10 is a high-mobility-group transcriptional regulator in early neural crest. Without Sox10, no glia develop throughout the peripheral nervous system. Here we show that Sox10 is restricted in the central nervous system to myelin-forming oligodendroglia. In Sox10-deficient mice progenitors develop, but terminal differentiation is disrupted. No myelin was generated upon transplantation of Sox10-deficient neural stem cells into wild-type hosts showing the permanent, cell-autonomous nature of the defect. Sox10 directly regulates myelin gene expression in oligodendrocytes, but does not control erbB3 expression as in peripheral glia. Sox10 thus functions in peripheral and central glia at different stages and through different mechanisms.

PMID:
11799060
PMCID:
PMC155320
DOI:
10.1101/gad.215802
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center